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B16 tumors are considered 'cold tumors' due to low immunogenicity, low levels of tumor immune infiltrate, and resistance to immunotherapies such as checkpoint inhibitors (e.g., anti-PD1)

Within minutes, GHK-Cu is absorbed and circulating through the bloodstream, where it can reach skin, hair follicles, joints, and connective tissue throughout the body exactly the kind of broad, systemic distribution that GHK-Cus mechanisms of action call for

Additionally, peripheral B cells are closely related to disease progression, as their frequency positively correlates with CRP levels and length of hospital stay, suggesting that these cells are potential markers for evaluating therapeutic response